Endocrine Abstracts

Introduction: Serum and intranodal levels of IGF1 and IGF-binding protein 3 levels (IGFBP3) were determined in patients with nodular thyroid diseases.Materials and methods: Demographic, clinicopathological and laboratorial caracteristics of the subjects were recorded. After performing fine needle aspiration biopsy, IGF1 and IGFBP3 levels were determined in blood and aspiration samples. Clinicopathological and laboratorial findings were analysed.<p cl...

Purpose: Most of the acromegaly cases are due to agrowth hormone-secreting pituitary adenomas of which immunohistochemical subtype seperated as sparsely granulated adenoma (SGA) and densely granulated adenoma (DGA). SGA’s were reported to have more aggressive clinical course and therapy resistance. We investigated our patients for these aspects.Method: Forty (F21, M19) patients with acromegaly who diagnosed and operated for pituitary adenoma at our...

Purpose: Diabetic Foot Ulceration (DFU) is common problem throughout the world and resulting in major economic consequences for the patients and country. We aim to describe estimated cost of illness between patients with DFU in southern Turkey.Methods: A total of 148 (F = 55, M = 93) patients with DFU were included in this retrospective study. We also included more than one admission of the patients with DFU. Patients characteri...

Background: Hypoparathyroidism is an uncommon disorder of calcium metabolism characterized by hypocalcemia, hyperphosphatemia, and reduced level of parathyroid hormone (PTH). The most common cause of hypoparathyroidism is accidental damage to the parathyroid glands during thyroid surgery. There are no formal guidelines for hypoparathyroidism management. The main goal of treatment is to improve the symptoms of hypocalcemia, to keep the serum calcium within the low normal range,...

Background: Currently, there is no satisfying treatment option other than gross total or subtotal resection in combination with adjuvant radiotherapy for the treatment of craniopharyngiomas. However, recurrence could occur in a substantial proportion of craniopharyngiomas despite gross total resection and radiotherapy. Human epidermal growth factor receptor 2 (HER-2/ErbB2) overexpression was determined in various human carcinomas and is associated with aggressive clinical beha...

Introduction: Aminoterminal pro B type natriuretic peptide (NT-pro BNP) is the inactive degradation product of pro BNP. Thyroid diseases are known to have effect on NT-pro BNP levels. In this study, we aimed to determine possible changes in NT-pro BNP levels in patients with thyroid dysfunctions.Material and method: Fifteen patients with hyperthyroidism, 8 with subclinical hyperthyroidism, 12 with hypothyroidism, 15 with subclinical hypothyroidism and 35...

Introduction: Presence of GH receptor in human skin and its appendages suggests a direct effect of GH on skin characteristics. Wet and oily skin due to hyperhidrosis and increased sebum production were described in acromegaly patients.Objective: The aim of the study was to examine the hydration via capacitance, sebum content, transepidermal water loss, pH and temperature of the skin in patients with acromegaly. The data were compared with that of control...

Objective: Thyroid hemiagenesis is a rare form of thyroid dysgenesis, in which one thyroid lobe fails to develop. The true prevalence of this rare abnormality is about 0.05–0.2% in normal population. We aimed to determine prevalence of thyroid hemiagenesis in patients with various thyroid disorders and a normal population in a mild to moderate iodine-deficient area.Subjects and methods: The clinical and thyroid ultrasonography records of 4.833 patie...

In new classification of autoimmune polyendocrine syndromes (APS), APS-3 has defined as combination of autoimmune thyroid disease and other autoimmune disease except hypoparathyroidism and Addison’s disease. The present report describes a patient with APS-3 and pseudomalapsorbtion of levothyroxine (LT4). Twenty-three year old woman was referred to our center with hypothyroidism due to Hashimoto’s thyroiditis (HT) despite the usage of high dose LT4 treatment. HT was d...

Introduction: Hemochromatosis is an iron storage disease characterized by iron deposition in parenchymal cells due to increased intestinal iron absorption. Iron overload leads to tissue damage and dysfunction particularly in the liver, pancreas, heart, joints, and pituitary gland. Panhypopituitarism is a clinical condition in which the anterior pituitary gland hormones are deficient. Herein we report a very rare case of panhypopituitarism due to hemochromatosis.<p class="a...